DNA repair and crossing over favor similar chromosome regions as discovered in radiation hybrid of Triticum
نویسندگان
چکیده
منابع مشابه
Chromosome Structure and Crossing Over.
A major obstacle to understanding classical genetic crossing over in higher organisms has been the lack of sufficient knowledge concerning the structure of chromosomes. Without accurate information, in particular, as to how the hereditary substance (DNA) is built into the chromosome, it may be premature to devise models depicting how that material may be recombined in crossing over. In recent y...
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Background: Single nucleotide polymorphisms in 8-oxoguanine DNA glycosylase-1 (OGG1) gene modulates DNA repair capacity and functions as one of the first lines of protective mechanisms against 8-hydroxy-2’-deoxyguanosine (8-OHdG) mutagenicity. OGG1-Cys326 gene polymorphism may decrease DNA repair function, causing oxidative stress due to higher oxidative DNA damage. The main purpose of this stu...
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The MRE11, RAD50, and XRS2 genes of Saccharomyces cerevisiae are involved in the repair of DNA double-strand breaks (DSBs) produced by ionizing radiation and by radiomimetic chemicals such as methyl methanesulfonate (MMS). In these mutants, single-strand DNA degradation in a 5' to 3' direction from DSB ends is reduced. Multiple copies of the EXO1 gene, encoding a 5' to 3' double-strand DNA exon...
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This paper proposes a general model for interference in genetic crossing over. The model assumes serial occurrence of chiasmata, visualized as a renewal process along the paired (or pairing) chromosomes. This process is described as an underlying Poisson process in which the 1st, n + 1th, 2n + 1th, etc., events are to be interpreted as realized chiasmata. Chromatid interference is described in ...
متن کاملThe Mre11 Complex Influences DNA Repair, Synapsis, and Crossing Over in Murine Meiosis
The Mre11 complex (consisting of MRE11, RAD50, and NBS1/Xrs2) is required for double-strand break (DSB) formation, processing, and checkpoint signaling during meiotic cell division in S. cerevisiae. Whereas studies of Mre11 complex mutants in S. pombe and A. thaliana indicate that the complex has other essential meiotic roles , relatively little is known regarding the functions of the complex d...
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ژورنال
عنوان ژورنال: BMC Genomics
سال: 2012
ISSN: 1471-2164
DOI: 10.1186/1471-2164-13-339